First pig kidney transplant patient dies in US

A porcine organ was given to the 62-year-old guy who was suffering from kidney disease that had progressed to the final stage in the middle of March. It has not yet been determined whether or not the transplant is connected to the Boston hospital.

The transplantation of a genetically engineered pig kidney into a living patient who was suffering from end-stage kidney disease was a first of its kind in the world. The transplant took place in the United States two months ago. The hospital made the announcement of his passing this past weekend, but they did not make any connection between the transplant at this time.

“The unexpected passing of Rick Slayman has left Mass General in a state of profound heartbreak. According to a statement that was issued by the hospital on Saturday, May 11, “We have no indication that this was a consequence of his recent transplant.” It was in March that surgeons at this facility in Boston, which is located in the northeastern part of the United States, transplanted the kidney of a genetically modified pig into this patient. This was a first that was touted as a new step towards a potential solution to the persistent lack of organ donors.

The patient, who was 62 years old, was currently experiencing chronic renal failure. At the time, the hospital said that he had made a “good” recovery from the procedure that lasted for four hours.

The transplantation of kidneys from genetically engineered pigs into brain-dead humans had already been accomplished with favorable results. A heart transplant from a genetically modified pig has also been performed on living individuals, however those patients have ultimately passed away. “Mr. Slayman will forever be seen as a beacon of hope for countless transplant patients around the world,” Massachusetts General Hospital stated on Saturday. “He will be deeply missed.” “We are filled with profound gratitude for his trust and his desire to advance xenotransplantation,” which refers to the process of transplanting organs from animals into human beings.

The lack of available organs is a persistent issue all across the world. Within the United States of America, there are over one hundred thousand individuals who are currently waiting for an organ transplant, with the kidney being the organ that is most frequently required. eGenesis, a biotechnology company based in Massachusetts, supplied the pig kidney that was utilized for the transplant. According to the hospital, the pig kidney had been changed to remove dangerous genes and add some human genes.

Rick Slayman, who was suffering from hypertension and type 2 diabetes, was given a human kidney transplant in 2018. However, the transplant began to fail five years later, and the patient was forced to begin dialysis following the operation.

Towards the end of April, the New York University Langone Hospital made the announcement that a genetically modified pig kidney had been transplanted into a living person for the second time. At the same time, the transplanted kidney was accompanied by a heart pump, which is a combination procedure that is not commonly performed. In September of 2021, surgeons from this New York hospital are responsible for performing the world’s first transplant of a kidney from a pig into a human patient who has lost consciousness.

Recent years have seen a rapid acceleration in the development of xenografts. Nevertheless, they also provide a problem due to the fact that the immune system of the receiver has a tendency to attack the foreign organ. The CRISPR technology was used to eliminate some pig genes and introduce human genes in order to lessen the likelihood of the animal being rejected. The genetic alterations were carried out in order to reduce the danger of rejection.

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